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Tuesday, March 2, 2021

CD Genomics Analyzes the Role of Microorganisms to Promote the Cancer Immunotherapy

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In recent years, some studies have found a close link between the intestinal microbes and the immune system, which provides a new way to improve the immune therapy by selectively modulating the intestinal bacteria.
High-throughput sequencing technology promotes cancer and immunology research, as well as individual immunity treatment. For example, high-throughput sequencing greatly promotes the understanding of cancer genome and intracellular mechanisms, and cancer genome analysis also reveals the target antigen epitope by immune system. While sequencing can also be used to determine the immune system library and monitor the clonal expansion&cell population concentration responding to tumor growth or treatment.
Role of microorganisms
In recent years, some studies have found a close link between the intestinal microbes and the
immune system, which provides a new way to improve the immune therapy by selectively modulating the intestinal bacteria.
Researchers have increased the ability of mice to attack tumor cells by introducing a special type of bacteria into the digestive tract of melanoma mice. This treatment has no much difference with that by using anti PD-L1 antibody.
The combination of oral administration of bacteria and injection of anti PD-L1 antibody almost completely eliminate tumor growth.
The results clearly demonstrate that specific intestinal bacteria play a rather surprising but extremely important role on the responses of enhanced immune cells to melanoma and many other types of tumors.
CD Genomics points out that Bifidobacterium is related to anti tumor effect, and only oral Bifidobacterium can improve the treatment effect with the same dose of anti-PD-L1, which almost completely inhibits tumor growth.
Ipilimumab is an FDA approved drug for the treatment of advanced melanoma, by targeting CTLA-4 to inhibit the immune response activated by antigen, and thus plays an anti tumor effect. However, the anticancer effect of Ipilimumab in the intestinal flora can be controlled by the Bacaeroides.
The greater the abundance of gut flora, the better the effect of anticancer drugs. Fecal microbial 16S RNA sequencing and qPCR can be used to identify if the Bcteroides in intestinal bacteria are involved in the anti-cancer effect of Ipilimumab drug. At the same time, it can also be used by animal experiment.
About the Author:
At CD genomics, our proprietary GenSeq™ technology provides the comprehensive metagenomic sequencing, revealing the hidden life and a variety of phenomena in microorganisms. The use of metagenomics can observe the microbial world, which lets us understand the their life differently.
Source from: https://cdgenomics281.newswire.com/news/cd-genomics-analyzes-the-role-of-microorganisms-to-promote-the-cancer-11736976

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